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Immunohistochemistry analysis indicated that chemotherapy-resistant patients had significantly higher expression levels of NRF2, GPX4 and SOD1 in tumor tissues compared to the sensitive ones

When to seek urgent medical help: Whilst most gastrointestinal side effects are mild and self-limiting, participants and clinicians should be alert to the following red-flag symptoms, which require prompt medical assessment: Severe or persistent abdominal pain (which may indicate pancreatitis or gallbladder disease) Repeated vomiting or an inability to keep fluids down Signs of dehydration (such as dizziness, dark urine, or reduced urine output) Yellowing of the skin or eyes (jaundice) Anyone who suspects they have experienced a side effect from a medicine including medicines received as part of a clinical trial should report it via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk)

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Acrolein exerts its toxic effects through inhalation, ingestion and dermal exposure

Understanding how these medications work provides important context for recognizing and managing potential side effects, including fatigue

Antioxidant (1,000mg): Neutralizes skin-damaging free radicals