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When NNMT is overactive, it consumes S-adenosylmethionine (SAM) and reduces levels of nicotinamide adenine dinucleotide (NAD+), a critical coenzyme involved in cellular energy production

10.1021/la00037a015 361 LeblancS

Microbiome 10 , 77 (2022)

IL-6 that modulates VEGF release and action and is accompanied by the increase in the generation of IL-8 that also acts as angiogenic factor in gastric cancer through the interaction with cognate receptors (CXCR1 and CXCR2) on endothelial cells ( 103-105)

Inflammatory skin diseases Various inflammatory skin diseases are attributed to the disruption of the skin barrier and aberrant structural components [61], and ferroptosis actively affects the epidermal barrier and skin homeostasis

10.1007/s12264-018-0269-8 151 WhittleB