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The reframing of GHK from "growth factor" to "copper-delivery peptide" was an important conceptual development that connected the peptide to broader research on copper biochemistry

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While essential for physiological signaling, excessive NO production in CF airway inflammation can dysregulate S-nitrosylation, contributing to pathology (Kimura, 2020)

Binds copper in a bioavailable complex

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Thus, treating with antioxidants not only improves OXPHOS functionality and reduces ROS production but also may improve -Ox, making both systems more efficient to reduce ROS-induced cell damage and energetic crisis in kidney disease