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Integrative oncology studies and protocols are a key translational interface in which TS are being evaluated, with the aim to comprehensively evaluate their therapeutic potential, safety, pharmacokinetics and clinical efficacy, attempting to connect preclinical mechanistic findings with evidence-based clinical practice

Bavachinin, a natural compound from Fructus Psoraleae, has been shown to reduce lipid accumulation in NAFLD by promoting fatty acid oxidation and inhibiting the cholesterol synthesis enzyme Farnesyl-diphosphate farnesyltransferase 1 (FDFT1), while also enhancing cell proliferation through its facilitation of the interaction between PCNA and DNA polymerase delta

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However, when confronted with external stimuli, dysregulation often occurs, leading to the onset of diseases

Etchegaray JP, Mostoslavsky R

New and emerging drug and gene therapies for Friedreich ataxia