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Cognitive improvement was observed after 8 weeks of treatment in both females and males, sustained through a 12-week study period, and accompanied by a concurrent reduction in amyloid plaques and neuroinflammation compared to intranasal saline-treated transgenic mice

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and Bonhoeffer T (2001) Morphological changes in dendritic spines associated with long-term synaptic plasticity Annu Rev Neurosci 24: 1071 -89