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Patients with a history of pancreatitis or gallbladder disease also warrant careful monitoring, as GLP-1 medications have been associated with gallstones and gallbladder inflammation in some cases

The most successful patients are those who view the drug as a partner to their diet and exercise, not a replacement for them

Topical bioavailability: Lower but meaningful

However, if your constipation doesnt improve with dietary changes such as drinking more water and increasing your fiber intake, or if you have a family history of colon cancer, consult your doctor

This one closes the loop: these drugs are not the end of anything

Biological Psychiatry, 74 (10), 720-726