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This is supported by multiple case series demonstrating delayed metastases and relapses when long-term follow-up was obtained

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The main two diagnostic scoring systems are: H 2 FPEF and HFA-PEEF

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The risks of renal impairment, volume depletion adverse reactions and urinary tract infection-related adverse reactions increased with worsening renal function [see Warnings and Precautions (5.2)]