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Both sit at the preclinical tier mechanistically plausible, supported by cell-culture and animal studies, but not confirmed by controlled human trials
Funding This work was supported by the National Natural Science Foundation of China (Grant 81720108030, 81773695, 81803475, 81373371, and 31871810), National Key Research and Development Project of China (2018YFE0208600), China Postdoctoral Science Foundation, the financial support by Key Lab for Drug Delivery & Tissue Regeneration (SS2018004), Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions
Initiation of urate-lowering treatment is often delayed, and once begun, many patients continue to have serum urate concentrations above recommended levels for urate crystal dissolution
Continue normal diet emphasizing protein and nutrient density
10.3390/ijms19051433 Int
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