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The authors explain the limitations: First, we did not measure GFR with iohexol clearance during the first weeks of the study, and the number of participants with cystatin C eGFR values was limited during the up-titration phase of the study

This would exclude the possible nonspecific contribution of the additional volume (as it may be the infusion into the anterior chamber to increase intraocular pressure above systolic pressure to induce ischemia ( Finally, the obtained findings should be summarized with the previous eye evidence

In: Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc