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Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA

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Reeves KD, Hassanein KM: Randomized, prospective, placebo-controlled double-blind study of dextrose prolotherapy for osteoarthritic thumb and finger (DIP, PIP, and trapeziometacarpal) joints: evidence of clinical efficacy

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Oxidative stress may then damage mitochondrial membranes and enzymes, further lowering ATP production and increasing the need for glutathione, SOD, catalase and other antioxidant defenses