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Leptin is produced not only in the adipose tissue but also in the gastrointestinal tract, particularly in the stomach, where it has been shown to protect the gastric mucosa against various topical irritants and ulcerogens, acting, at least in part, via enhancement of mucosal blood flow due to increased production of nitric oxide (NO) caused by upregulation of NO synthase as well as the activation of brain-gut axis pathways (48, 49)

It is also used to treat moderate to severe obstructive sleep apnea (OSA) in adults with obesity

You can use it as a liquid or with a pad

doi: 10.3390/cells12121581 153

Giustarini D, Milzani A, Dalle-Donne I, Rossi R

Type 2 diabetes is a long-term condition when your blood sugars (HbA1c) become too high because the body does not produce or use insulin normally