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Evaluating the effect of CD38 treatment on brain IL-1, revealed a reduction at a protein level when analyzing the cortices of these same mice, a phenomenon that was also observed when each independent experiment was separately analyzed (Fig

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To rule out inferiority, the FDA required CVOTs to show an upper boundary risk ratio of 1.3 (post approval), utilizing a two-sided 95% confidence interval (CI), for major adverse cardiovascular events (MACE) [55]