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Specifically, consistent effect estimates were observed across multiple independent cohorts, as demonstrated for schizophrenia (FinnGen: OR = 0.65, 95% CI [0.560.76]

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Neurochem Res 47:29923002 Wu H, Luan Y, Wang H, Zhang P, Liu S, Wang P et al (2022) Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway

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This dual effect on both positive and negative reinforcement mechanisms suggests that GLP-1RAs may reduce alcohol use through multiple neurobiological pathways