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A Glossary for Use in Toxicity and Carcinogenicity Studies

Clin Immunol

However, DOPAL can be detoxified by NAD(P) + -dependent aldehyde dehydrogenase (ALDH) or reduced by aldehyde/aldose reductase (ALR/AR) to form the inactive 3,4-dihydroxyphenylethanol, or further oxidized to non-toxic 3,4-dihydroxyphenylacetic acid where the aldehyde moiety is replaced by a carboxyl group [32]

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This is the most common outcome at advisory hearings additional impurity characterization, an immunogenicity workup, or a structured human-exposure summary, brought back at a later meeting

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