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Retatrutide efficacy The phase 3 randomised, doubleblind, placebocontrolled TRIUMPH-1 trial evaluated the safety and efficacy of retatrutide for the treatment of patients with obesity or overweight, moderate-to-severe obstructive sleep apnoea and obesity, and knee osteoarthritis pain

however, repeated administration may cause tachyphylaxis due to depletion of endogenous norepinephrine stores

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Gu S, Wang X, Qiao Q, Gao W, Wang J, Dong H