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Wegovy is part of a class of medications that help control appetite and are most effective with lifestyle changes (Wharton et al., 2025)

Reduced SCFA production means less GLP-1 stimulation from L-cells

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Notably, similar to the native GLP-1, binding of SR18 to GLP-1R also induces structural changes in the conserved motifs (Figure 17) in comparison to the inactive (PDB: 6LN2) GLP-1R (Wu et al., 2020), which is crucial for intracellular signaling of GLP-1R