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If the container is formed of two or more members of one or more materials, the three-way surfaces are sealed in any suitable manner so that an opening for filling the unit dose is formed

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However, with the more recently introduced SGLT2 inhibitors and GLP-1 receptor agonists having shown impressive cardiovascular risk reduction in addition to glycemic control efficacy, these newer agents may also be considered as first-line therapies in patients with pre-existing cardiovascular or renal disease (Garber 2020)

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A recent study evaluated its use in preventing kidney injury during angiography (imaging of blood vessels)

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