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Centrally, GLP-1 activates GLP-1 receptors located in the nucleus tractus solitarius and dorsal motor nucleus of the vagus within the brainstem, leading to inhibition of parasympathetic output and a reduction in gastric smooth muscle tone [2, 28]

Its selectivity profile makes it particularly useful for researchers seeking to isolate GH-axis effects without confounding corticotroph stimulation

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