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Tran DH, May HI, Li Q, Luo X, Huang J, Zhang G, Niewold E, Wang X, Gillette TG, Deng Y, Wang ZV (2020) Chronic activation of hexosamine biosynthesis in the heart triggers pathological cardiac remodeling

Only 5 patients stopped the trial from gastrointestinal side effects and only 5% of the 9mg and 12mg arms had to stop the trial for any adverse events

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Researchers identified several factors including heart failure, type 2 diabetes, substance abuse, anticoagulant use and hypertension that contributed to much of the individualized treatment effect for kidney cancer risk