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The issue is relative impact

Instead, MPLs were linked to beneficial effects on intestinal health, notably an increase in colonic goblet cells, suggesting an enhancement of the gut barrier

[DOI] [PubMed] [Google Scholar] 61.Trevaskis JL, Wittmer C, Athanacio J, Griffin PS, Parkes DG, Roth JD

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Compared to obese mice treated with Veh, KPCY and LLC tumors in mice treated with RETA failed to engraft 33-50% of the time and did not grow appreciably, which suggests that RETA may impact both cancer risk and progression