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These peptides stimulate the pituitary glands somatotroph cells to release growth hormone (GH) through either GHRH (growth hormone-releasing hormone) receptor agonism or ghrelin receptor agonism

These clinical findings are particularly relevant for MCAS patients

The evidence base for use of these drugs, either for off-label indications or as non-approved drugs, is wanting

Efficacy and safety of duloxetine in painful diabetic peripheral neuropathy: a systematic review and meta-analysis of randomized controlled trials

doi: 10.1016/j.lfs.2017.12.015 11