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In this transport system, CPT and CACT can regulate the transport mode according to the changes of metabolites in mitochondria, playing an important role in the transport and metabolism of fat, carbohydrates, proteins, and toxic substances produced by abnormal metabolism (Figure 1) (9, 10)

Mills EL, Ryan DG, Prag HA et al (2018) Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

**Potential Risk of Pancreatitis**: While rare, there have been reports of pancreatitis in some patients taking these medications

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