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In the Krebs cycle, NAD+ functions as a coenzyme for the rate-limiting enzymes alpha ketoglutarate dehydrogenase, isocitrate dehydrogenase, and malate dehydrogenase

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Funding for this work was supported by the Massachusetts General Hospital, Harvard Medical School, Stanford University School of Medicine, UC Davis MIND Institute, and an Autism Center of Excellence grant awarded by the National Institute of Child Health and Development (Grant P50 HD093079)

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