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Understanding the Innate Repair Receptor (IRR) The innate repair receptor is a heteromeric receptor complex composed of: Erythropoietin receptor (EPOR) -common receptor (CD131) This receptor is activated in response to: Tissue injury Hypoxia Inflammation Oxidative stress Activation of the IRR triggers a cascade of protective signaling designed to: Limit tissue damage Reduce inflammation Promote cellular survival Support repair rather than scarring ARA-290 was designed specifically to activate this receptor without activating erythropoiesis
The nitrobenzoxadiazole derivative MC3181 blocks melanoma invasion and metastasis
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From Pubchem IUPAC Name: (4S)-4-[[(2S)-2-aminopropanoyl] amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl] amino]-5-oxopentanoic acid Synonyms: Epithalone, alanyl-glutamyl-aspartyl-glycine, epitalon, epithalon Molecular Formula: C14H22N4O9 Molecular Weight: 390.35 g/mol Sequence: Ala-Glu-Asp-Gly CAS number: 307297-39-8 PubChem CID: 219042 Epithalon was initially researched and developed in Russia by Dr
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