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10.1002/edm2.163 [DOI] [PMC free article] [PubMed] [Google Scholar] 23.Zhang L, Yang M, Ren H, Hu H, Boden G, Li L, et al

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Experimental data point oxidative stress as one of the factors that contributes to aquaporin-1 up-regulation since administration of the antioxidant melatonin not only reduced protein levels but also mechanical allodynia and appearance of aquaporin-1-positive fibers below laminae I and II (Nesic et al., 2008)

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MariTide has completed a Phase 2 trial that was published and shared through press releases, the New England Journal of Medicine, and at the American Diabetes Associations annual meeting in Chicago