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The -hydroxy--butyrolactone was then acetylated with acetyl chloride to give -acetoxy--butyrolactone

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also demonstrated that the compound did not illicit an increase in blood pressure or heart rate in DIO NHPs at the efficacious dose of 0.5 mg/kg/24 h SC infusion over positive control LY2112688, further suggesting cardiac liabilities to be molecule specific (45)

The side effect profiles of semaglutide and tirzepatide differ in several respects

The AUDIT questionnaire (Alcohol Use Disorders Identification Test) was given to determine if there was alcohol abuse