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7.3.6 Clinical translation Successful translation of ferroptosis-targeted therapies requires methodical progression through several key stages: validation of candidate biomarkers in well-characterized human cohorts, optimization of inhalation formulations for consistent pulmonary deposition, and demonstration of safety and efficacy through rigorously designed clinical trials
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183 The intake of HSD has also been shown to inhibit enterotoxigenic Bacteroides fragilis (ETBF)-promoted colon carcinogenesis by decreasing the expression of IL-17A and iNOS, thereby inhibiting inflammation
[33] [34] However, too low and excessively high levels of choline may adversely affect fetal health and development
An alignment of MrGST1 protein with anthocyanin-related GSTs identified in other dicotyledonous plants indicated that all of these GSTs had the conversed GST-N-Phi (Thioredoxin-like superfamily), GST-C-Phi (GSTC-family superfamily) domains, and high-homology sites (indicated as red boxed) in the GST family (Figure 1B)
