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Whilst there is a gradual decline in semaglutide plasma concentrations between doses, several other factors typically contribute more significantly to day-to-day glucose fluctuations than the medication's pharmacokinetics alone

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The data matrices obtained from GC-MS were normalized to the total peak area and transferred to the SIMCA-P+ (v13.0, Umetrics, Umea, Sweden) program for multivariate analysis such as principal component analysis (PCA) and partial least squares differentiation analysis (PLS-DA) for the assessment of separability of the groups

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