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Importantly, the ECD of GLP-1R undergoes a remarkable orientation change from the closed TMD-interacting conformation to the extended active conformation during peptide binding and activation

Fuster, J

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Treatment with a NOX inhibitor, a catalytic antioxidant, and a scavenger of reactive oxidized compounds gamma-ketoaldehydes, have all been shown to prevent experimental TLE seizure-induced neuronal death (Kim et al., 2013