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Semaglutide works as a long-acting GLP-1 receptor agonist, remaining active in your bloodstream for seven days after a single subcutaneous injection

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In healthy volunteers ( N = 54), administration of a proton pump inhibitor, omeprazole (40 mg once daily), resulted in a slight non-statistically significant increase in exposure to semaglutide that was not considered to be clinically relevant and no dose adjustment is recommended with these agents [34]

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Some clinicians may use semaglutide off-label in selected patients for metabolic support, such as insulin resistance or weight reduction when other approaches have not worked

Anstrom KK, Miczek KA, Budygin EA (2009)