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mTOR activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosus

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription

demonstrated that puerarin enhances antiPD-L1 efficacy by suppressing ROS production, thereby reducing CAF-mediated physical barriers, increasing T-cell infiltration, and alleviating immunosuppression in the tumor microenvironment (150)

Headache and fatigue can occur, especially during dose increases

For oily or combination skin, use a light amount and spread well until fully absorbed without overapplying

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