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Interestingly, these same GLP-1R agonists are also potential treatments for obesity due to the potent suppressive effects on food intake and body weight that have been reported in both humans and animal models (2, 25, 26, 36, 43)

Common mistake: Increasing the dose because nothing is "felt." Community protocols hold at 300mcg for at least 4 weeks before considering adjustments

The main downsides of Wegovy are digestive side effects and slightly lower average weight loss compared with Mounjaro in some studies

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GIP(330)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release