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The oncogene K-Ras activates Nrf2 transcription through the Mek-Erk-Jun signaling pathway and reduces the ROS levels in primary fibroblasts

The timing differential is why sequential dosing (Semax first, Selank 3045 minutes later) creates stronger synergy than simultaneous administrationSemax establishes cholinergic tone before Selank amplifies it through GABA receptor modulation

The p values observed in this study suggest that larger sample numbers would not change this result

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