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Pirfenidone Pirfenidone (5-methyl-1-phenylpyridin-2(1 H)-one) is a non-peptide synthetic molecule with high oral bioavailability, that exerts anti-fibrotic, anti-inflammatory, antioxidant, and apoptosis-regulating effects [213, 214]
[DOI] [PubMed] [Google Scholar] 87.Havemeyer A., Grnewald S., Wahl B., Bittner F., Mendel R., Erdlyi P., Fischer J., Clement B
10.1210/jc.2018-01221 28 KalantarM.HosseiniS
The SIRT1 expression is decreased in the high-fat diet (HFD)-induced DKD mice model and HG-treated SV40 MES13 cells, accompanied by the increased thioredoxin-interacting protein (Txnip) expression and nuclear translocation of XBP1s (a transcription factor that binds to Txnip promoters)
Shufelt CL, Bairey Merz C