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J Biol Chem 285:61186126 Turrens JF (2003) Mitochondrial formation of reactive oxygen species

[57] [58] It was not until 1747 that James Lind formally demonstrated that scurvy could be treated by supplementing the diet with citrus fruit, in one of the first controlled clinical experiments reported in the history of medicine

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Its use remains strictly confined to the academic and industrial RUO frame, with specific quality requirements (disulfide mapping, 98%+ purity, characterized endotoxins) separating serious suppliers from opaque vendors