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Tauber and coworkers, who published the first study demonstrating that hyperghrelinaemia starts early in life, prior to hyperphagia and obesity [39], concluded for an impaired development of the ghrelin system in subjects with PWS, starting with excessive UAG, which then decreases, followed by an excessive increase in AG and a relative deficit in UAG

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Clinical data from the TAZPOWER trial showed improvements in muscle strength and cardiac function in treated patients

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