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While these recommendations are based on observations of thyroid C-cell tumors in rats, it is still unknown whether tirzepatide may also cause thyroid tumors, including medullary thyroid carcinoma, in humans

Investigators underlined an increase in heart rate was observed in other GLP-1 receptor agonist studies and changes in heart rate from baseline to week 72 in SURMOUNT-1 indicate the observed heart rate increase may attenuate with continued treatment

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How do their mechanisms compare

The study was conducted in 41 countries, and its complete results will be presented at a meeting of the American College of Cardiology in Philadelphia at the end of 2023

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