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Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage

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Sublingual B12, which bypasses the gastrointestinal tract, is the least invasive and potentially most cost-effective option, especially for individuals with impaired absorption, making it an attractive alternative for long-term and patient-friendly management (Vidal-Alaball et al., 2006)

Potential Benefits & Side Effects Observations from phase 2 and phase 3 clinical trials

High-resolution photography was taken for all participants at baseline, week 6, and week 10, with an additional photo at week 14 for non-responders (Figure 4)