Hypertension is characterized by activation and excitation of sympathetic nerve system
2.4 Other Diseases Oxidative damage caused by overactivation of the immune response is the key pathogenic factor of chronic inflammation conditions, such as Crohns disease (CD), rheumatoid arthritis, and the inflammatory bowel diseases (Shimizu et al., 2015), but whether this protective mechanism is related to gut microbiota has not been studied
Mercury poisoning is one of the most common types of heavy metal poisoning
All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications
*Correspondence: Zhiquan Yang, [email protected] This article was submitted to Cellular Neuropathology, a section of the journal Frontiers in Cellular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Trial Structure Duration: 48 weeks of treatment Participants: 338 adults randomized 2:1:1:1:1:2:2 to placebo or retatrutide groups Doses tested: 1mg, 4mg, 8mg, 12mg (all with slow titration from 2mg starting dose) Lifestyle intervention: All participants received counseling on diet (500 kcal/day deficit) and exercise (150 min/week) Primary endpoint: Percent weight change at 24 weeks Key secondary endpoints: Weight change at 48 weeks, proportion achieving 5%, 10%, 15% loss The trial used a slow titration protocol to minimize side effects: all groups except the 1mg dose started at 2mg weekly and escalated every 4 weeks
