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The third mechanism whereby diabetes upregulates ANGII/AT1R is ACE2 downregulation, resulting in local ANG (1-7) reduction and, consequently, in an imbalance of the RAS

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Additionally, liraglutide reduced microglial activation in the TNC, as evidenced by decreased Iba-1 expression and reduced levels of pro-inflammatory cytokines IL-1 and TNF- [94]

The synergistic combination of glucagon-like peptide-1 (GLP-1) receptor agonists with other anti-diabetic agents presents a promising approach for glycemic control in type 2 diabetes

Paracetamol (5001000 mg every 46 hours, maximum 4 g daily) represents a safe first-line option for most patients

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