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Carnitine supplements have been shown to help improve sperm motility and morphology, especially in cases where the cause of infertility remains unknown

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Daily challenge with mildronate (MD) for 5 successive days before and after a solo dose of MTX acheived 76% and 20% elevation of BUN as well as 96% and 23% elevation in serum creatinine compared with control and MTX groups, respectively

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It advanced to human clinical trials where it demonstrated effectiveness in the treatment of related ischemic injuries (Maples et al., 2004)