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The main ingredient in most GLP-1 patches is berberine, a plant-derived substance, along with other herbal supplements.While some of these ingredients may lead to modest weight loss (1-3 pounds) when taken orally, there is no scientific evidence supporting their effectiveness when delivered through the skin

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Phase 2 T2D trial, NEJM 2023) indicate that gastrointestinal adverse effects are the most frequently reported side effects, particularly during dose escalation

Potential tumor promotion : Given its angiogenic properties, there is theoretical concern it could contribute to tumor growth or neovascularization in certain contexts

GLP-1 Cost Management, Coverage, and Demand Skyrocketing costs are one challenge

The study would not have been possible without the use of artificial intelligence to weed through dozens of proteins in a class called prohormones