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Tirzepatide (a dual GIP/GLP-1 agonist) may produce slightly different body composition changes than semaglutide alone, with some research suggesting modestly better lean mass preservation

Furthermore, because both can lead to a decrease in blood pressuresemaglutide through weight loss and metabolic changes, and spironolactone as its primary functionpatients may experience lightheadedness or dizziness if their blood pressure drops too low

The goal is manageable hunger that allows for controlled eating, not a complete absence of hunger signals

This can be attributed to its dual action on GIP and GLP-1 pathways

January 6, 2026 3,097 Total MDL Cases As of January 2026, the GLP-1 weight loss drug MDL includes 3,063 pending cases

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