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We can see very clearly that this is specific to medications that are working through GLP-1 receptor pharmacology. Two additional industry-funded trials, which were not included in the meta-analysis because of differences in study design, reported similar responses between those with and without the variants

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Tirzepatide is a dual GIP/GLP-1 receptor agonist, showing 21-23% greater weight reduction in head-to-head studies published in 2023

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Data was represented as amount of bound Photo-Click cholesterol relative to SNAP/FLAG-hGLP-1R