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ICV IgG1-treated mice maintained stable body weight, while all doses of ICV mGIPR-Ab/P3 led to substantial weight loss (Extended Data Fig

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[30] [31] A systematic review published in 2024 found that tirzepatide is well tolerated and not associated with pancreatitis, [32] but later case reports have found that pancreatitis followed initiation of treatment with tirzepatide

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