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2013), the vast majority of potential Nrf2 modulators are electrophiles with an inherent propensity to interact with off-target cellular nucleophiles

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Supplementary Information References Summary Keywords brain aging, aging metabolism, brain energy metabolism, neurometabolic coupling, neuro-glia-vascular system, metabolism model, aging brain model, differential equations model Citation Shichkova P, Coggan JS, Kanari L, Boci E, Favreau C, Antonel SM, Keller D and Markram H (2025) Breakdown and repair of metabolism in the aging brain

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