Some people experience bile acid malabsorption leading to diarrhea
From my own clinical experience, which could be skewed because I only serve people that don't get well in the traditional sector, but I would say 85 percent of people are walking around either with a diagnosed thyroid condition and being inappropriately managed or walking around being told they do not have a thyroid condition when they actually do
Animal research has revealed both the central and peripheral effects of GLP-1RA in modulating brain-gut signals, appetite circuits, and cravings through dopaminergic and serotonin pathways
However, the medications are usually not alternated frequently or used simultaneously
One thing to keep in mind is that maintenance dosing is not the same as micro-dosing
For example, semaglutide 2.4mg (Wegovy) has demonstrated approximately 15% weight loss at 68 weeks in clinical trials, while liraglutide 3mg (Saxenda) typically achieves around 8% at 56 weeks