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The completion of a Phase I trial is a significant milestone, as its primary objective is to assess safety and tolerability in human subjects

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[DOI] [PubMed] [Google Scholar] 59.Nkooyeh B, Neyestani T

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Rodent models support the importance of AMPAR activation and increased BDNF as essential for depression improvement with ketamine, as antidepressant effects are not observed if BDNF is neutralized or AMPAR inhibited [58, 59]