With an up gene amplitude threshold of 0.40 (equivalent to a 1.5-fold induction) and a down gene amplitude threshold of 0.40 (equivalent to a 1.5-fold repression), we discover that 76 genes lay above the up threshold and 6 lay below the down threshold
Aging is associated with functional and phenotypic alterations in the microcirculation, including endothelial dysfunction, oxidative stress, chronic low-grade inflammation, and microvascular rarefaction (reduced number and combined length of small vessels in a given volume of tissue)[289]
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In a systematic review and meta-analysis, Mavrakanas et al
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