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This is most relevant for weight-based peptides like kisspeptin (dosed in mcg/kg) and less relevant for receptor-saturating peptides like BPC-157, where tissue concentration at the injury site matters more than total body distribution

Clinical trial data shows average weight loss of approximately two percent of body weight per month during the first six months, with this rate declining gradually over time

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Finally, the study overlapped with a period of limited supply of semaglutide in the US market, wherein some patients may not have had access to semaglutide or experienced treatment interruptions that precluded them from meeting study inclusion criteria

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Because there were fewer Severe patients Post-Baseline, this effect was more marked Post-Baseline